Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interspecies quorum sensing signals modulate multicellular organization and enhance contact-dependent antagonism in Vibrio cholerae.

Nature communications·2026
Same author

Genome sequence of <i>Shigella</i> phage vB_EcoM_SS01.

Microbiology resource announcements·2026
Same author

Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens.

PLoS biology·2026
Same author

The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data.

PLoS medicine·2026
Same author

Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes.

PLoS biology·2026

Related Experiment Video

Updated: May 8, 2026

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

15.9K

Recent advances in modelling Shigella infection.

Sydney L Miles1, Kathryn E Holt2, Serge Mostowy1

  • 1Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Trends in Microbiology
|February 29, 2024
PubMed
Summary

Innovative models like organ-on-chip, zebrafish, mouse, and human infection models are crucial for understanding Shigella pathogenesis and developing new treatments for this diarrheal disease. These tools accelerate the discovery of novel therapeutics and vaccines.

Keywords:
Shigellaanimal modelepidemiologyhost responseinnate immunityvaccine

More Related Videos

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells
08:56

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells

Published on: May 24, 2018

5.6K
Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
04:56

Author Spotlight: Advancements in Understanding and Combatting Shigella Infections

Published on: February 9, 2024

928

Related Experiment Videos

Last Updated: May 8, 2026

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

15.9K
Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells
08:56

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells

Published on: May 24, 2018

5.6K
Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
04:56

Author Spotlight: Advancements in Understanding and Combatting Shigella Infections

Published on: February 9, 2024

928

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pathogen Research

Background:

  • Shigella causes significant global diarrheal disease burden.
  • Antimicrobial resistance and lack of vaccines necessitate novel therapeutics.
  • Understanding Shigella infection mechanisms is critical for public health.

Purpose of the Study:

  • To review innovative technologies and animal models for studying Shigella infection.
  • To examine the contributions of organ-on-chip, zebrafish, mouse, and human infection models.
  • To discuss the future of Shigella infection modeling.

Main Methods:

  • Review of recent literature on organ-on-chip models for biomechanics.
  • Analysis of zebrafish models for epidemiology and innate immunity.
  • Examination of oral mouse models for inflammasome biology.
  • Evaluation of controlled human infection models for vaccine assessment.

Main Results:

  • Organ-on-chip models advance understanding of Shigella biomechanics.
  • Zebrafish models offer insights into Shigella epidemiology and immune response.
  • Mouse models reveal new inflammasome pathways and protective mechanisms.
  • Human infection models bridge research to clinical impact and vaccine evaluation.

Conclusions:

  • Novel models are essential for advancing Shigella research.
  • These models accelerate the development of therapeutics and vaccines.
  • Future research should leverage these innovative approaches for Shigella control.