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Updated: Jul 1, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
A guideline on the molecular ecosystem regulating ferroptosis
Enyong Dai1, Xin Chen2, Andreas Linkermann3,4
1Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, China. daiey@jlu.edu.cn.
Abstract:
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
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