Clinical outcomes of simultaneous pancreas-kidney transplantation in elderly type II diabetic recipients
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Age does not significantly impact outcomes for simultaneous pancreas-kidney transplantation (SPK) in type II diabetes patients. This study found comparable survival, graft loss, and metabolic profiles regardless of recipient age at transplantation.
Area Of Science
- Nephrology
- Endocrinology
- Transplantation Medicine
Background
- Simultaneous pancreas-kidney transplantation (SPK) is a vital treatment for type II diabetes (T2DM) patients with end-stage renal disease.
- The influence of recipient age on SPK outcomes, particularly in T2DM patients, requires further clarification.
Purpose Of The Study
- To investigate the association between recipient age at transplantation and mortality, graft loss, and metabolic profiles in T2DM SPK recipients.
- To determine if age influences long-term success and health status post-SPK.
Main Methods
- Retrospective cohort study of 103 T2DM SPK recipients, divided into groups based on age (>=55 vs. <55 years).
- Analysis included Kaplan-Meier survival estimates, competing risk analysis for graft loss, and mixed regression models for metabolic parameters (HbA1c, glucose, lipids, eGFR).
Main Results
- No significant differences in 5-year survival or graft loss were observed between the age groups.
- Metabolic profiles, including HbA1c, glucose, lipid levels, and eGFR, showed no age-related disparities post-transplantation.
- Perioperative outcomes and complications were comparable across different age strata.
Conclusions
- Recipient age at the time of SPK does not appear to be a significant predictor of mortality, graft loss, or metabolic outcomes in T2DM patients.
- These findings support considering older T2DM patients as suitable candidates for SPK, challenging age-related concerns.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Detailed History: Understanding the patient's symptoms is critical. It includes inquiring about abdominal pain, weight loss, and digestive issues, which are common in chronic pancreatitis.
Physical Examination: This might reveal abdominal tenderness, jaundice, and signs of malnutrition,...
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...