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  11. Disparity Of Serum Uric Acid Threshold For Ckd Among Hypertensive And Non-hypertensive Individuals

Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals

Bowen Zhu1,2,3, Fang Li1,2,3, Weidong Zhang1,2,3

  • 1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Renal Failure
|March 1, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Hypertension and high serum uric acid (sUA) significantly increase Chronic Kidney Disease (CKD) risk. Optimal sUA thresholds differ between hypertensive and non-hypertensive individuals, highlighting the need for tailored management strategies.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Hypertension and elevated serum uric acid (sUA) are critical factors in Chronic Kidney Disease (CKD) development.
  • Understanding their interactive effects is crucial for effective CKD prevention and management.

Purpose of the Study:

  • To investigate the interactive effect of sUA and hypertension on CKD risk.
  • To identify optimal sUA thresholds for CKD risk stratification in Chinese adults with and without hypertension.

Main Methods:

  • Analysis of 4180 individuals from the China Health and Retirement Longitudinal Study (CHARLS) (2011-2015).
  • Inclusion of a hospital-based cohort from Zhongshan Hospital (2019-2021) for kidney injury assessment (KIM-1).
  • Utilized interaction effect analysis and propensity score matching (PSM) for robust evaluation.
Keywords:
CHARLSHypertensionchronic kidney diseaseserum uric acid

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Main Results:

  • Higher CKD prevalence observed in hypertensive individuals (10.2%) compared to non-hypertensive (3.9%).
  • Significant synergistic effect of sUA and hypertension on CKD risk.
  • Comparable CKD risk at sUA < 4.55 mg/dL (hypertensive) and < 5.58 mg/dL (non-hypertensive).

Conclusions:

  • Moderate sUA levels pose a significant CKD risk in middle-aged hypertensive patients.
  • Stricter sUA control is warranted for hypertensive individuals to mitigate CKD risk.