Related Experiment Video
Updated: Jul 1, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease
Zhuoyan Zhao1, Ying Fu1, Huan Lian1
1Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Insights
New research shows angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like 4 (ANGPTL4), and fatty acid-binding protein 4 (FABP4) are independent risk factors for coronary artery disease (CAD). These factors offer potential for CAD diagnosis and treatment.
Area of Science:
- Cardiovascular Research
- Metabolic Syndrome
- Biomarker Discovery
Background:
- Coronary artery disease (CAD) is significantly influenced by lipid metabolism.
- Emerging factors like angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like 4 (ANGPTL4), and fatty acid-binding protein 4 (FABP4) are implicated in CAD pathogenesis.
Purpose of the Study:
- To investigate the association between ANGPTL3, ANGPTL4, FABP4, and coronary artery disease (CAD).
- To evaluate the potential of these lipid metabolism factors as diagnostic and therapeutic targets for CAD.
Main Methods:
- Enrolled 284 inpatients with suspected CAD, categorized by coronary angiography.
- Measured serum levels of ANGPTL3, ANGPTL4, FABP4, and tumor necrosis factor-α (TNF-α) via ELISA.
- Utilized multivariate logistic regression and ROC curve analysis to identify risk factors and diagnostic values.
Main Results:
- Significant differences in TNF-α, FABP4, ANGPTL3, and ANGPTL4 levels were observed between CAD and non-CAD groups.
- FABP4, ANGPTL3, and ANGPTL4 were identified as independent risk factors for CAD after adjusting for confounders.
- A combination of elevated ANGPTL3, ANGPTL4, and FABP4 levels demonstrated the highest diagnostic value for CAD.
Conclusions:
- ANGPTL3, ANGPTL4, and FABP4 are confirmed as independent risk factors for coronary artery disease (CAD).
- These lipid metabolism factors hold significant clinical value for the diagnosis and management of CAD.
Background:
Lipid metabolism related factors, such as angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like 4 (ANGPTL4), fatty acid-binding protein 4 (FABP4) are newly discovered factors that can affect coronary artery disease (CAD). In this study, we aimed to investigate the relationship between CAD and these lipid metabolism factors.
Hypothesis:
ANGPTL3, ANGPTL4, and FABP4 may provide a new method for the control of CAD risk factors and the prevention and treatment of CAD.
Methods:
We enrolled 284 consecutive inpatients with suspected CAD and divided them into CAD and non-CAD groups based on the coronary angiography results. Serum ANGPTL3, ANGPTL4, FABP4, and tumor necrosis factor-α (TNF-α) levels were estimated using the enzyme-linked immunosorbent assay. Multivariate logistic regression was used to assess the risk factors for CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.
Results:
The serum TNF-α, FABP4, ANGPTL3, and ANGPTL4 values showed a significant difference between the CAD and non-CAD groups (p < .05). After adjusting for confounding factors, the FABP4, ANGPTL3, and ANGPTL4 levels were independently associated with CAD (p < .05). The ANGPTL3 expression level was an independent risk factor for CAD in patients with hypertension, but not in those without hypertension. The ANGPTL3 > 67.53 ng/mL, ANGPTL4 > 29.95 ng/mL, and FABP4 > 1421.25 ng/L combination had the highest diagnostic value for CAD.
Conclusion:
ANGPTL3, ANGPTL4, and FABP4 were identified as independent risk factors for CAD and have valuable clinical implications for the diagnosis and treatment of CAD.
More Related Videos
13:26Visualization and Quantification of Mesenchymal Cell Adipogenic Differentiation Potential with a Lineage Specific Marker
Published on: March 31, 2018
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...