Absence of GATA3/FOXA1 co-expression predicts poor prognosis in upper tract urothelial carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.The co-expression of GATA binding protein 3 (GATA3) and forkhead box A1 (FOXA1) is linked to upper tract urothelial carcinoma (UTUC) progression. Lack of GATA3/FOXA1 co-expression indicates poor prognosis and may serve as a biomarker for UTUC.
Area Of Science
- Oncology
- Molecular Biology
- Urology
Background
- GATA binding protein 3 (GATA3) and forkhead box A1 (FOXA1) are individually implicated in upper tract urothelial carcinoma (UTUC) progression.
- Understanding the prognostic implications of their co-expression is crucial for patient management.
Purpose Of The Study
- To evaluate the prognostic value of GATA3 and FOXA1 co-expression in UTUC patients.
- To investigate the correlation between GATA3/FOXA1 expression and clinical outcomes.
Main Methods
- 108 UTUC tissue samples and 24 normal urothelial tissues were analyzed using a 132-site microarray.
- Immunohistochemistry (IHC) was performed to measure GATA3 and FOXA1 expression.
- Kaplan-Meier survival and Cox regression analyses assessed UTUC prognosis.
Main Results
- GATA3 expression positively correlated with FOXA1 expression (P=0.031).
- Absence of GATA3/FOXA1 co-expression (GATA3-/FOXA1-) was associated with extensive tumor necrosis (P=0.001).
- GATA3-/FOXA1- correlated with shorter Disease-Free Survival (DFS) (P=0.001) and Cancer-Specific Survival (CSS) (P<0.001).
- Extensive necrosis was an independent prognostic factor for CSS (P=0.030).
Conclusions
- A positive correlation exists between GATA3 and FOXA1 expression in UTUC.
- GATA3-/FOXA1- is linked to extensive tumor necrosis and poor prognosis in UTUC.
- GATA3/FOXA1 co-expression status may serve as a potential prognostic biomarker for UTUC.
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