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Updated: Jul 1, 2025
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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
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Clinical features and outcomes of COVID-19 patients with concomitant herpesvirus co-infection or reactivation: A
Shiny Talukder1, Paroma Deb2, Monira Parveen3
1Department of Microbiology, Rangamati Medical College, Rangamati, Bangladesh.
New Microbes and New Infections
|March 1, 2024
Summary
COVID-19 patients frequently experience co-infections with Herpesviridae, impacting clinical outcomes. Steroid use and specific blood markers are associated with increased risk of herpesvirus reactivation in these patients.
Area of Science:
- Virology
- Infectious Diseases
- Clinical Medicine
Background:
- COVID-19 (Coronavirus Disease 2019) has been associated with various Herpesviridae co-infections since its emergence.
- These co-infections range from mild skin issues to severe, life-threatening conditions.
Purpose of the Study:
- To systematically review and analyze the association between clinical features and outcomes of COVID-19 and concomitant Herpesviridae infections.
- To identify key factors influencing the prognosis of patients with dual infections.
Main Methods:
- A comprehensive literature search was performed across major electronic databases (PubMed, Cochrane, Scopus, Web of Science).
- Data extraction and risk of bias assessment (using RoBANS tool) were conducted independently by two reviewers.
- Nineteen studies comprising 539 patients with both COVID-19 and Herpesviridae infections were included.
Main Results:
- Cytomegalovirus (CMV) reactivation was the most frequently detected co-infection.
- Reactivation of multiple herpesviruses was associated with increased mortality.
- Steroid dosage and usage showed a significant association with Herpesviridae reactivation.
- Elevated D-dimer and CRP levels, longer ICU stays, and invasive mechanical ventilation were significantly associated markers.
Conclusions:
- This systematic review highlights the significant clinical implications of Herpesviridae co-infections in COVID-19 patients.
- Findings can assist clinicians in better assessing and managing COVID-19 cases with co-infections, particularly regarding steroid management and monitoring of specific biomarkers.
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