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Related Concept Videos

Pleura of the Lungs01:13

Pleura of the Lungs

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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Pulmonary Cycle: Exhalation01:17

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In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
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Pneumothorax-I01:26

Pneumothorax-I

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A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
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Size-Exclusion Chromatography01:08

Size-Exclusion Chromatography

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In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...
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Related Experiment Video

Updated: Jul 1, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
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Separating Out Pulmonary Sequestration.

Linda H Pham1, Yassine Hamdaoui2, Ghazarian Zeron3

  • 1Internal Medicine, HCA Riverside, Riverside, USA.

Cureus
|March 1, 2024
PubMed
Summary
This summary is machine-generated.

Pulmonary sequestration (PS) is a rare congenital lung malformation. Early diagnosis and surgical excision are key for symptomatic patients, improving outcomes for this often-misdiagnosed condition.

Keywords:
congenital lung abnormalitiesintralobar pulmonary sequestrationpulmonary diseasepulmonary sequestrationrecurrent pneumonia

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Area of Science:

  • Congenital Pulmonary Malformations
  • Thoracic Surgery
  • Diagnostic Imaging

Background:

  • Pulmonary sequestration (PS) is a rare congenital anomaly comprising 1-6% of all pulmonary malformations.
  • It is characterized by non-functional lung tissue lacking normal tracheobronchial communication and pulmonary circulation blood supply.

Observation:

  • A 28-year-old female presented with recurrent pulmonary infections and chest pain.
  • Computed tomography angiogram (CTA) revealed an 8.9 x 8.3 cm intralobar pulmonary sequestration in the right lower lobe with aberrant arterial supply.

Findings:

  • The patient underwent successful robotic resection of the right lower lobe sequestration, confirmed by pathology.
  • CTA is preferred over digital subtraction angiography for visualizing lung parenchyma and vascular anatomy, aiding surgical planning.

Implications:

  • Pulmonary sequestration is frequently misdiagnosed due to its varied presentation mimicking other chest conditions.
  • Prompt diagnosis and surgical management are crucial for symptomatic intralobar pulmonary sequestration to prevent recurrent infections and complications.