Related Experiment Video
Updated: Jul 1, 2025
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Septic Pylephlebitis in the Setting of COVID-19 Infection: A Case Report
Anosh Khan1, Montaser Alrjoob1, Mahrukh A Khan1
1Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
COVID-19 can cause rare, severe blood clots in the portal vein system, leading to serious complications. Prompt diagnosis and anticoagulation are crucial for managing this hypercoagulable state in patients with prolonged fever.
Area of Science:
- Internal Medicine
- Infectious Diseases
- Vascular Medicine
Background:
- Portal vein thrombophlebitis is a rare complication associated with hypercoagulable states.
- COVID-19 has been identified as a potential trigger for such thrombotic events.
Observation:
- A 74-year-old female with comorbidities (hypertension, diabetes, lymphoma) developed COVID-19.
- Initial symptoms included fever, leukocytosis, and epigastric tenderness, progressing to hypotension and acute hypoxic respiratory failure.
- Diagnosis revealed portal vein thrombosis (PVT) and superior mesenteric vein thrombosis.
Findings:
- The patient was treated with antibiotics and anticoagulation (heparin, then warfarin).
- Recurrence presented as watery diarrhea, fever, abdominal pain, and fatigue, diagnosed as pylephlebitis and liver abscesses.
- Successful treatment involved six weeks of antibiotics and ongoing anticoagulation.
Implications:
- Prolonged fever in COVID-19 patients may signify extensive thrombosis in unusual locations.
- Early recognition and management of venous thromboembolism are critical in COVID-19 patients.
- This case highlights the importance of considering thrombotic complications in COVID-19, even at atypical sites.
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:29Pneumonia II: Pathophysiology
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:26Tonsillitis II: Management