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Updated: Jul 1, 2025

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
SUNCT syndrome secondary to multiple sclerosis: Not only trigeminal neuralgia
Giada Giuliani1, Chiara Zilli1, Francesca Caramia1
1Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Background:
Facial pain in multiple sclerosis is often due to trigeminal neuralgia but atypical pictures can be observed.
Case Presentation:
A man with primary progressive multiple sclerosis developed severe unilateral facial pain in the right orbital region. Spontaneous and triggered attacks were associated with ipsilateral conjunctival injection and lacrimation. A diagnosis of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing was made, and symptoms significantly improved with lamotrigine.
Conclusion:
Pain is poorly investigated in multiple sclerosis, with a dramatic impact on patients' life quality. In this light, standardized evaluation of pain is needed to improve patient management.
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