Expression of PTGS2 along with genes regulating VEGF signalling pathway and association with high-risk factors in locally advanced oral squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Cyclooxygenase-2 (COX-2) and VEGF signalling genes are significantly upregulated in oral squamous cell carcinoma (OSCC). This finding highlights their potential impact on patient clinical outcomes in this cancer.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- PTGS2 encodes cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis.
- COX-2 is suggested to mediate the VEGF signalling pathway.
- In silico analysis in head and neck cancers shows PTGS2 and VEGF pathway gene co-expression.
Purpose Of The Study
- To investigate the expression patterns of PTGS2 and VEGF signalling genes in oral squamous cell carcinoma (OSCC).
- To determine the association between PTGS2 and VEGF signalling genes in OSCC.
Main Methods
- Gene expression analysis (RT-PCR) of tumour and normal tissue samples from 24 OSCC patients.
- Comparison of in vivo results with in silico data from TCGA.
- Co-expression analysis to assess the relationship between PTGS2 and VEGF pathway genes.
Main Results
- PTGS2, VEGFA, KDR, CXCR1, and CXCR2 were significantly upregulated in OSCC tumour tissues compared to normal tissues.
- In silico analysis showed a similar pattern, with notable exceptions for CXCR2.
- Co-expression analysis revealed a significant positive correlation between PTGS2 and most VEGF signalling genes, with a negative correlation for VEGFB.
Conclusions
- PTGS2 and key VEGF signalling genes are upregulated in oral squamous cell carcinoma.
- These upregulated genes likely play a significant role in the clinical progression of OSCC.
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