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Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Carles Falcon1,2, Grégory Operto1, José Luis Molinuevo3,4
1Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Methods in Molecular Biology (Clifton, N.J.)
|March 1, 2024
Summary
Alzheimer
Area of Science:
- Neuroscience
- Biomarkers
- Medical Imaging
Background:
- Alzheimer's disease (AD) is increasingly viewed as a continuum.
- Pathophysiological biomarkers like cerebrospinal fluid (CSF) Aβ-42, t-tau, and p-tau appear before AD symptoms.
- Magnetic resonance imaging (MRI) tracks in vivo structural and functional changes.
Purpose of the Study:
- To describe neuroimaging methods for combining CSF metabolite data with imaging analyses.
- To explore the structural correlates of AD-related biomarkers.
- To advance understanding of AD as a continuum.
Main Methods:
- Utilizing cerebrospinal fluid (CSF) biomarker analysis.
- Employing magnetic resonance imaging (MRI) for in vivo studies.
- Describing methods for integrating CSF and imaging data.
Main Results:
- The combination of CSF data and imaging analyses offers a synergistic approach.
- This integration aids in understanding structural correlates of AD biomarkers.
- Methods are detailed for researchers to combine these data types.
Conclusions:
- Integrating CSF biomarkers and neuroimaging data provides deeper insights into Alzheimer's disease.
- This combined approach is crucial for studying AD as a continuum.
- The described methods facilitate research into the structural underpinnings of AD pathology.
