Developments and Trends of Nanotechnology Application in Sepsis: A Comprehensive Review Based on Knowledge...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Infectious Diseases

Background:

• Sepsis remains a critical global health challenge with high mortality rates.
• Despite advancements, effective diagnostic and therapeutic strategies are continuously sought.
• Nanotechnology presents a promising avenue for improving sepsis management.

Purpose of the Study:

• To conduct a bibliometric analysis of research trends and hotspots in nanotechnology for sepsis.
• To review current applications of nanomaterials in sepsis diagnostics and therapeutics.
• To discuss challenges and future perspectives for nanotechnology in sepsis research.

Main Methods:

• Bibliometric analysis of scientific literature on nanotechnology and sepsis.
• Comprehensive review of research hotspots, including diagnostics and therapeutics.
• Discussion of nanomaterial-based strategies, including biomimetic nanoparticles.

Main Results:

• Identified key research trends and hotspots in nanotechnology applications for sepsis.
• Highlighted nanotechnology-enhanced biosensors, nanoscale imaging, and nanoplatforms for therapy.
• Discussed the potential of biomimetic nanoparticles and their translational promise.

Conclusions:

• Nanotechnology shows significant potential for advancing sepsis diagnosis and treatment.
• Biomimetic nanoparticles offer innovative therapeutic strategies with reduced immune response.
• Addressing challenges is crucial for realizing the full translational potential of nanotechnology in sepsis care.