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Relationship Between Hepatitis C Infection and Treatment Status and Coronavirus Disease 2019-Related Hospitalizations

Ana Aslanikashvili1, Charlotta Rylander1, Tinatin Manjavidze1,2

  • 1Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.

The Journal of Infectious Diseases
|March 1, 2024
PubMed

Insights

Hepatitis C virus (HCV) treatment before COVID-19 infection reduced hospitalization odds. Untreated HCV infection increased COVID-19 hospitalization risk, underscoring the importance of HCV management.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • The impact of HCV on COVID-19 outcomes requires further investigation.
  • Understanding these interactions is crucial for patient management during pandemics.

Purpose of the Study:

  • To assess the influence of HCV infection and treatment status on COVID-19 hospitalization rates in Georgia.
  • To determine if prior HCV treatment affects severe COVID-19 outcomes.
  • To provide data for public health strategies regarding co-infected patients.

Main Methods:

  • Analysis of Georgian health registry data from 2020-2021.
  • Inclusion of COVID-19 positive individuals.
  • Categorization based on HCV infection and treatment status, with logistic regression analysis.

Main Results:

  • Individuals treated for HCV showed decreased odds of COVID-19 hospitalization.
  • Untreated HCV-viremic individuals faced higher odds of hospitalization.
  • Anti-HCV-positive nonviremic individuals also exhibited increased hospitalization odds.

Conclusions:

  • HCV management and treatment prior to COVID-19 infection are linked to better hospitalization outcomes.
  • Effective HCV treatment may mitigate severe COVID-19 consequences.
  • These findings emphasize the critical role of managing chronic viral infections during public health crises.
Abstract

Keywords:
COVID-19Georgiadirect-acting antiviralshepatitis C virusregistry study

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