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Identification of depression in patients with acute coronary syndrome using multiple serum biomarkers
Jae-Min Kim1, Ju-Wan Kim1, Hee-Ju Kang1
1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
Background:
Biomarkers for depression in patients with acute coronary syndrome (ACS) have not been identified.
Methods:
This study evaluated multiple serum biomarkers for depressive disorders after ACS. Thirteen serum biomarkers associated with seven functional systems, along with sociodemographic/clinical characteristics, were evaluated in 969 patients within 2 weeks after ACS onset (acute phase). In total, 711 patients were evaluated for depressive disorder using DSM-IV criteria 1 year later (chronic phase). Logistic regression was used for the analysis.
Results:
Depressive disorders were observed in 378 patients (39.0%) in the acute phase of ACS and 183 patients (25.7%) in the chronic phase. The weighted scores of five serum biomarkers (high-sensitivity C-reactive protein, interleukin-6, homocysteine, troponin I, and creatine kinase-MB) were significantly associated with depressive disorder diagnosis in the acute phase, and the weighted scores of three other biomarkers (tumor necrosis factor-alpha, interleukin-1 beta, and homocysteine) were significantly associated with depressive disorders in the chronic phase, in a dose-dependent manner after adjusting for relevant covariates (all P-values <0.001).
Conclusions:
The combination of several serum biomarkers exhibited robust associations with depressive disorders in both the acute and chronic phases of ACS.
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