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Updated: Jul 1, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
Unleashing a safe and potent pro-senescence anti-tumor strategy
Shasha Chen1, Beicheng Sun2, Zhongjun Dong3
1Department of Allergy, the First Affiliated Hospital of Anhui Medical University and Institute of Clinical Immunology, Anhui Medical University, Hefei 230032, China; Innovative Institute of Tumor Immunity and Medicine (ITIM), Hefei 230032, China; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei 230032, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China.
Abstract:
Inducing senescence in tumor cells can stimulate anti-tumor immune responses. In this issue of Cancer Cell, Colucci et al. demonstrate that the combination of the RAR agonist Adapalene with the chemotherapy drug Docetaxel enhances tumor-suppressing senescence and activates an anti-tumor immune response through natural killer cells.
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