Type 2 diabetes associated with areca nut usage: A systematic review and meta-analysis
Wen-Yi Liu1, Zhu Liduzi Jiesisibieke2, Ching-Wen Chien3
1Department of Health Policy Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Shanghai Bluecross Medical Science Institute, Shanghai, China; Shanghai International Medical Center, Shanghai, China; Institute for Hospital Management, Tsing Hua University, Shenzhen Campus, Shenzhen, China.
Preventive Medicine
|March 1, 2024
Summary
Chewing areca nuts is linked to an increased risk of developing type 2 diabetes, particularly for ex-chewers. Individuals who chew areca nuts should monitor diabetes biomarkers.
Area of Science:
- Epidemiology
- Metabolic Diseases
- Public Health
Background:
- Areca nut chewing is a prevalent habit in many parts of the world.
- The association between areca nut consumption and type 2 diabetes requires further investigation.
- Understanding chewing status (current vs. ex-chewers) may clarify the risk.
Purpose of the Study:
- To evaluate the association between areca nut chewing and type 2 diabetes.
- To determine if chewing status modifies this association.
Main Methods:
- Systematic review and meta-analysis of population-based studies.
- Searched Cochrane Library, PubMed, and EMBASE databases up to May 21, 2023.
- Included three studies conducted in Taiwan.
Main Results:
- Combined current or ex-areca nut chewers showed a higher likelihood of developing diabetes (OR=1.45).
- Ex-chewers had a significantly higher risk of diabetes (OR=1.53) compared to never chewers.
- No significant association was found for current chewers versus never chewers; however, males showed increased risk (OR=1.55).
Conclusions:
- Evidence suggests a link between areca nut chewing and type 2 diabetes development.
- Areca nut chewers are advised to monitor diabetes-related biomarkers.
- Further research is needed to clarify risks for current chewers and females.
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