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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Expression and function of VISTA on myeloid cells

Siyu Li1, Geng Wang1, Yan Ren1

  • 1Health Science Center, Ningbo University, Ningbo, China.

Biochemical Pharmacology
|March 1, 2024
PubMed

V-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, including neutrophils, monocytes, macrophages, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs). In addition, we will discuss whether the functions of VISTA on these cells impact the disease processing.

Keywords:
DCsMDSCsMacrophagesNeutrophilsVISTA

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