Current status and future trends of the global burden of MASLD
Lei Miao1, Giovanni Targher2, Christopher D Byrne3
1Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD on healthcare systems, thus further highlighting the urgent need for global efforts to tackle this common and burdensome liver condition. We emphasize the clinical relevance of early interventions and a holistic approach that includes public health strategies to reduce the global impact of MASLD.
Insights
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over a third of adults globally. Early intervention and public health strategies are crucial to manage this widespread liver condition and its economic impact.
Area of Science:
- Hepatology
- Public Health
- Epidemiology
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide.
- Affecting over 33% of the global adult population, MASLD poses a significant health challenge.
- The condition is linked to numerous adverse hepatic and extrahepatic outcomes.
Purpose of the Study:
- To provide a comprehensive overview of the global incidence and prevalence of MASLD.
- To review the adverse health outcomes associated with MASLD.
- To highlight the economic burden and the need for global intervention strategies.
Main Methods:
- This study is a comprehensive narrative review.
- It synthesizes global data on MASLD incidence and prevalence.
- It examines associated health outcomes and economic impacts.
Main Results:
- MASLD is the most common chronic liver disease globally, impacting over one-third of adults.
- The review details significant hepatic and extrahepatic complications of MASLD.
- A substantial economic burden on healthcare systems is associated with MASLD.
Conclusions:
- Urgent global efforts are required to address the widespread impact of MASLD.
- Early interventions and a holistic approach, including public health strategies, are essential.
- Reducing the global burden of MASLD necessitates coordinated action.
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