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Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and

Yixuan Wang1,2, Feifei Li1,2, Linshuang Mao1,2

  • 1Department of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Journal of Nanobiotechnology
|March 1, 2024
PubMed
Abstract

Insights

Molybdenum disulfide nanodots (MoS2 NDs) promote collateral formation in diabetic mice by enhancing endothelial cell function and activating autophagy. These nanodots offer a dual therapeutic approach for improving blood supply in type 2 diabetes mellitus patients.

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cardiovascular Research

Background:

  • Impaired collateral formation worsens prognosis in type 2 diabetes mellitus (T2DM) patients with cardiovascular disease.
  • Current treatments for enhancing collateral formation are inadequate.
  • Endothelial autophagy and reactive oxygen species (ROS) scavenging are key targets for improving angiogenesis.

Purpose of the Study:

  • To investigate molybdenum disulfide nanodots (MoS2 NDs) for enhancing collateral formation and prognosis in T2DM.
  • To elucidate the underlying mechanisms of MoS2 NDs in promoting angiogenesis.

Main Methods:

  • In vivo studies using ischemic tissues of diabetic mice.
  • In vitro experiments on endothelial cell proliferation, migration, and tube formation under high glucose/hypoxia.
  • Mechanistic investigations involving ROS scavenging and molecular pathway analysis (cAMP/PKA-NR4A2).

Main Results:

  • MoS2 NDs significantly improved collateral formation and blood resupply in diabetic mice.
  • MoS2 NDs enhanced endothelial cell proliferation, migration, and tube formation in vitro.
  • MoS2 NDs scavenge ROS and activate the cAMP/PKA-NR4A2 pathway, promoting autophagy and mitigating endothelial cell damage.

Conclusions:

  • MoS2 NDs demonstrate dual therapeutic functions: ROS scavenging and autophagy activation.
  • The synergy between autophagy and antioxidation is crucial for MoS2 NDs' efficacy.
  • MoS2 NDs represent a promising, cost-effective, and biocompatible agent for promoting collateral formation in diabetic contexts.
Keywords:
AutophagyCollateral formationMolybdenum disulfide nanodotsReactive oxygen speciesType 2 diabetes mellitus

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