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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Effect Of Sarcopenia And Frailty On Outcomes Among Patients With Brain Metastases.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Effect Of Sarcopenia And Frailty On Outcomes Among Patients With Brain Metastases.

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Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
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Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

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Effect of sarcopenia and frailty on outcomes among patients with brain metastases.

Mervyn Jun Rui Lim1, Zheting Zhang2, Yilong Zheng3

  • 1Division of Neurosurgery, National University Hospital, Singapore, Singapore. mervynlim@u.nus.edu.

Journal of Neuro-Oncology
|March 2, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Sarcopenia, indicated by reduced psoas muscle area, and frailty increase mortality and hospitalization in brain tumor patients. Clinical Frailty Scale (CFS) and muscle measurements can help assess surgical risks.

Keywords:
AgingBrain metastasesBrain tumorFrailty

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Area of Science:

  • Oncology
  • Neurosurgery
  • Geriatrics

Background:

  • Sarcopenia and frailty are linked to poor outcomes in cancer patients.
  • Limited data exist on their impact in patients with brain metastases.

Purpose of the Study:

  • To investigate the effects of sarcopenia and frailty on clinical outcomes in patients undergoing surgical resection of brain metastases.

Main Methods:

  • Retrospective analysis of 145 patients who had surgical resection of brain metastases (2011-2019).
  • Psoas muscle cross-sectional area and temporalis thickness were measured.
  • Frailty assessed using the Clinical Frailty Scale (CFS) pre- and post-operatively.
  • Cox and linear regression analyses were used for mortality, recurrence, and hospitalization duration.
Oncology
Sarcopenia

Main Results:

  • Reduced psoas cross-sectional area independently predicted higher mortality (HR=2.68) and recurrence (HR=2.31).
  • Post-operative CFS independently predicted higher mortality (HR=1.88).
  • Post-operative CFS (β=15.69) and increase in CFS (β=11.71) were associated with longer hospital stays.

Conclusions:

  • Psoas muscle area and post-operative frailty are significant risk factors for mortality in surgically treated brain metastases.
  • Frailty impacts hospitalization duration, highlighting the need for pre-operative assessment.
  • Measuring psoas muscle area and CFS can aid in risk stratification for surgical candidates.