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Updated: Jul 1, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Successful treatment of lupus protein-losing enteropathy with belimumab: A case report
Marenori Kojima1, Hironari Hanaoka2, Kaito Aoki1
1Division of Rheumatology, Center for Rheumatic Diseases, Seirei Yokohama Hospital, Yokohama, Kanagawa, Japan.
Abstract:
Lupus protein-losing enteropathy (LUPLE) is a rare condition in patients with systemic lupus erythematosus (SLE). Since the causes and exact pathological mechanism have not been elucidated, appropriate treatment has not been determined. Here, we report the case of a 69-year-old woman with systemic lupus erythematosus who developed LUPLE which was successfully treated with belimumab without an increase in glucocorticoid dose. This case suggests that belimumab monotherapy may be a treatment option for LUPLE.
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