Related Experiment Video

Updated: Jul 1, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

2.6K

E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases

Shilong You1, Jiaqi Xu1, Yushan Guo1

  • 1Department of Cardiology, First Hospital of China Medical University, Shenyang, Liaoning, China.

Molecular Aspects of Medicine
|March 2, 2024
PubMed

Insights

WWP2, a key E3 ubiquitin ligase, regulates cellular homeostasis and diverse biological processes. This review explores its roles in health and disease, highlighting therapeutic potential.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • E3 ubiquitin ligases are critical for cellular homeostasis, targeting proteins for ubiquitination.
  • WWP2 is an E3 ubiquitin ligase with significant roles in various biological processes.
  • Dysregulation of WWP2 is implicated in numerous diseases.

Approach:

  • This review synthesizes current knowledge on WWP2's functions.
  • It covers WWP2's biochemical, physiological, and pathophysiological roles.
  • It also identifies future research directions and therapeutic opportunities.

Key Points:

  • WWP2 regulates DNA repair, gene expression, signal transduction, and cell-fate decisions.
  • It plays a crucial role in tumorigenesis, skeletal development, immune regulation, and cardiovascular disease.
  • Understanding WWP2's mechanisms offers insights into disease pathogenesis.

Conclusions:

  • WWP2 is a vital regulator with broad implications in human health and disease.
  • Further research into WWP2 is warranted for potential therapeutic interventions.
  • This review provides a comprehensive overview of WWP2's multifaceted roles.
Keywords:
CancerDiseaseE3 ubiquitin ligaseUbiquitinationWWP2

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