Related Experiment Video
Updated: Jul 1, 2025
12:19
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
977
Cancer energy reprogramming and the immune responses
Xingxing Yuan1, Serge Yannick Ouedraogo2, Muhammed Trawally3
1Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150006, China; First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Cytokine
|March 2, 2024
Summary
Cancer cells reprogram their energy metabolism, impacting the tumor microenvironment and immune cells. This review explores these mechanisms and immune responses, highlighting future directions for cancer therapy.
Area of Science:
- Oncology
- Immunology
- Cellular Metabolism
Background:
- Cancer is characterized by uncontrolled cell growth, angiogenesis, and metastasis, influenced by the tumor microenvironment (TME).
- While nuclear mutations were historically focused on, mitochondria are increasingly recognized for their role in cancer pathogenesis.
- Cellular metabolism and metabolic reprogramming are intrinsically linked to genetic changes in cancer.
Purpose of the Study:
- To review cancer energy reprogramming mechanisms and associated enzyme degradation pathways.
- To elucidate cancer pathogenicity, focusing on reduced lactate production.
- To detail specific immune cell responses to distinct energy reprogramming strategies in cancer.
Main Methods:
- Literature review of recent oncology and immunology studies.
- Analysis of cancer energy metabolism and its impact on the tumor microenvironment.
- Synthesis of data on immune cell metabolic responses to cancer energy reprogramming.
Main Results:
- Cancer cells exhibit significant metabolic reprogramming, affecting the TME and immune cell function.
- Reduced lactate production is a key feature in certain cancer pathogenicity pathways.
- Distinct energy reprogramming strategies elicit specific immune cell metabolic responses.
Conclusions:
- Understanding cancer's altered energy metabolism is crucial for developing novel therapeutic strategies.
- Targeting metabolic reprogramming in cancer offers potential for harnessing host immune responses.
- Further research is needed to fully elucidate and exploit the interplay between cancer metabolism and immunity.
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