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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
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Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis
Angela Ammirabile1, Federico Mastroleo2, Giulia Marvaso3
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Milan, Pieve Emanuele 20090, Italy; Department of Diagnostic and Interventional Radiology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Milan, Rozzano 20089, Italy.
Research on human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is growing rapidly. Emerging trends include AI in diagnosis and new biomarkers, highlighting the need for clinical trials to improve patient outcomes.
Area of Science:
- Bibliometrics
- Oncology
- Epidemiology
Background:
- Human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is a significant health concern.
- Understanding research trends is crucial for advancing diagnosis and treatment.
Purpose of the Study:
- To evaluate scientific interest, collaboration patterns, and emerging trends in HPV+ OPSCC research.
- To analyze the evolution of HPV+ OPSCC research from 1987 to 2022.
Main Methods:
- A bibliometric analysis of 5200 documents from the Scopus database.
- Analysis of publication trends, country productivity, citation impact, journal representation, collaboration networks, and keyword co-occurrence.
- Factorial analysis of keywords to identify thematic clusters and emerging topics.
Main Results:
- Publications on HPV+ OPSCC show a consistent annual growth rate of 19.94%, peaking in 2021.
- Key research areas include epidemiology, diagnosis, prevention, and therapeutic options.
- Emerging trends focus on Artificial Intelligence (machine learning, radiomics) and diagnostic biomarkers (circulating tumor DNA).
Conclusions:
- Bibliometric analysis underscores the importance of research in HPV+ OPSCC prevention, diagnosis, and treatment.
- Further clinical trials are essential to optimize management and improve patient outcomes.
- The study identifies key areas for future research and development in HPV+ OPSCC.
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