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Updated: Jul 1, 2025
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Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
Published on: May 23, 2025
248
OPTN/SRTR 2022 Annual Data Report: Liver.
Allison J Kwong1, W Ray Kim2, John R Lake3
1Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA.
Summary
Liver transplant activity reached an all-time high in 2022, with improved survival rates for deceased and living donor transplants. Despite progress, challenges remain for pediatric liver transplant candidates.
Area of Science:
- Hepatology and Transplant Surgery
- Organ Transplantation Statistics
- Public Health and Epidemiology
Background:
- Liver transplantation is a critical treatment for end-stage liver disease.
- Transplant activity and outcomes are influenced by donor availability, recipient factors, and disease prevalence.
- Monitoring trends in liver transplant activity is essential for resource allocation and policy development.
Purpose of the Study:
- To analyze the trends and outcomes of liver transplantation in the United States in 2022.
- To compare deceased donor versus living donor liver transplant activity and survival.
- To evaluate outcomes for adult and pediatric liver transplant recipients, including those with specific conditions like hepatocellular carcinoma.
Main Methods:
- Analysis of national liver transplant data from 2022, including recipient demographics, donor types, and diagnoses.
- Comparison of transplant waiting list dynamics, pretransplant mortality, and posttransplant survival rates.
- Evaluation of outcomes for simultaneous liver-kidney transplants and hepatocellular carcinoma exception cases.
Main Results:
- A record 9,527 liver transplants were performed in 2022, a 52% increase over the decade, with 93.7% from deceased donors.
- Alcohol-associated liver disease and metabolic dysfunction-associated steatohepatitis were leading diagnoses; survival rates improved, nearing pre-pandemic levels.
- Living donor liver transplants showed superior 5-year survival rates in both adult and pediatric recipients compared to deceased donor transplants.
Conclusions:
- Liver transplant activity and survival outcomes continue to improve, yet significant numbers remain on the waiting list.
- Living donor liver transplantation offers better long-term survival, highlighting its importance.
- While pediatric outcomes have improved, challenges persist, with a notable number of children dying or becoming too sick for transplant.
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