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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jul 1, 2025

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Published on: May 5, 2020

Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues

Xu Cao¹, Dilip Thomas¹, Luke A Whitcomb²

¹Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, United States of America; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States of America.

Journal of Molecular and Cellular Cardiology

|March 2, 2024

Summary

No abstract available in PubMed .

Keywords:

Engineered heart tissue Human induced pluripotent stem cell Ionizing radiation Radiation-induced heart disease γ-Rays

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