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Multifunctional polysaccharide/metal/polyphenol double-crosslinked hydrogel for infected wound
Yun Duan1, Fuchen Jiang1, Qing Li1
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China.
Carbohydrate Polymers
|March 2, 2024
Summary
This study developed a novel chitosan hydrogel incorporating chlorogenic acid and zinc ions for bacterial-infected wounds. This advanced wound dressing promotes faster healing and offers potent antimicrobial and anti-inflammatory effects.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Infectious Diseases
Background:
- Bacterial-infected wounds pose significant public health risks, with limited efficacy of traditional dressings and antibiotic resistance issues.
- Chitosan-based hydrogels show promise due to biocompatibility, antimicrobial properties, and hemostatic capabilities.
- There is an urgent need for advanced wound dressings with enhanced antimicrobial activity and accelerated wound repair.
Purpose of the Study:
- To develop a multifunctional, bi-dynamic network hydrogel for treating bacterial-infected wounds.
- To evaluate the hydrogel's properties, including adhesion, injectability, mechanical strength, biodegradability, and biocompatibility.
- To assess the hydrogel's efficacy in promoting wound healing in a bacterial infection model.
Main Methods:
- Synthesized a hydrogel using chitosan grafted with chlorogenic acid (CA-ECS), oxidized pullulan polysaccharides (OP), and zinc ions (Zn2+).
- Characterized the hydrogel's physical, mechanical, and biological properties.
- Evaluated the hydrogel's performance in a rat model of full-thickness skin wounds infected with *S. aureus*.
Main Results:
- The CA-ECS/OP/Zn2+ hydrogel exhibited strong adhesion, good injectability, high mechanical strength, and was biodegradable and biocompatible.
- Incorporation of Zn2+ and chlorogenic acid (CA) enhanced mechanical properties, antioxidant, and antimicrobial activities.
- In vivo studies showed the hydrogel possessed anti-inflammatory, angiogenic, and folliculogenic properties, accelerating wound healing.
Conclusions:
- The developed CA-ECS/OP/Zn2+ hydrogel is a promising multifunctional material for treating bacterial-infected wounds.
- The hydrogel effectively promotes wound healing by reducing inflammation and enhancing tissue regeneration.
- This advanced hydrogel offers a potential alternative to conventional treatments for challenging wound infections.
