Related Experiment Video
Updated: Jul 1, 2025
13:35
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
10.5K
Sarcopenic obesity is associated with adverse outcomes after kidney transplantation: a retrospective cohort study
Yue Li1,2, Tingyu Chen3, Zhen Zhang3
1Department of Urology, West China Hospital, Sichuan University, 37# Guoxue Alley, Chengdu, 610041, Sichuan, People's Republic of China.
International Urology and Nephrology
|March 2, 2024
Summary
Sarcopenic obesity before kidney transplant is a significant risk factor for mortality and adverse outcomes. This condition independently increases the risk of death and complications post-transplantation.
Area of Science:
- Nephrology
- Transplantation Medicine
- Geriatrics
Background:
- Sarcopenia is a known poor prognostic factor in kidney transplant recipients.
- The specific impact of sarcopenic obesity on kidney transplantation outcomes remains under-explored.
Purpose of the Study:
- To investigate the effect of sarcopenic obesity on outcomes following kidney transplantation.
Main Methods:
- Retrospective analysis of kidney transplant recipients (2015-2019).
- Pretransplant CT scans used to assess sarcopenia and visceral obesity.
- Recipients classified into four groups based on sarcopenia and obesity status.
Main Results:
- Sarcopenic obesity identified as an independent risk factor for mortality (aHR, 5.861; P=0.007).
- Associated with increased risks of delayed graft function, perioperative infections (incision and pulmonary), and 3-month readmission.
- Impaired graft renal function noted, but no significant correlation with death-censored graft survival or quality of life.
Conclusions:
- Pre-transplant sarcopenic obesity is an independent predictor of mortality.
- Sarcopenic obesity is linked to multiple unfavorable outcomes after kidney transplantation.
