The effect of body mass index on mortality, peritonitis, technique proficiency and residual renal function in...

Area of Science:

• Nephrology
• Internal Medicine
• Public Health

Background:

• Rising global obesity rates affect the chronic kidney disease (CKD) population.
• Conflicting data exists regarding complications in underweight versus obese peritoneal dialysis (PD) patients.
• Understanding Body Mass Index (BMI) impact on PD outcomes is crucial.

Purpose of the Study:

• To compare residual renal function (RRF), peritonitis, technique proficiency, and mortality in PD patients across different BMI groups.
• To contribute regional data to the existing literature on obesity and CKD.
• To clarify the relationship between BMI and PD-related complications.

Main Methods:

• Retrospective analysis of 404 PD patients from March 2005 to November 2021.
• Patients categorized into underweight, normal weight, overweight, and obese based on BMI.
• Comparison of RRF, mortality, technique proficiency, and peritonitis rates among BMI groups.

Main Results:

• No significant differences were observed in technique proficiency or time to first peritonitis between BMI groups (p > 0.05).
• Multivariate analysis indicated that BMI did not significantly affect mortality risk (HR 1.196, p = 0.488).
• The study included 44 underweight, 199 normal weight, 110 overweight, and 55 obese patients.

Conclusions:

• Body Mass Index (BMI) does not appear to influence RRF, peritonitis, technique proficiency, or mortality in PD patients.
• Mortality in PD patients may be associated with factors beyond BMI, such as mean albumin levels and loss of RRF.
• Further research is needed to identify all factors influencing mortality in this population.