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Influence of abdominal fat distribution and inflammatory status on post-operative prognosis in non-small cell lung
Mengtian Ma1,2, Muqing Luo1, Qianyun Liu3
1Department of Radiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan Province, People's Republic of China.
Journal of Cancer Research and Clinical Oncology
|March 2, 2024
Summary
High visceral fat area (VFA) is linked to better survival in non-small cell lung cancer (NSCLC) patients. Low subcutaneous fat area (SFA) also improves outcomes, while inflammation markers (SII, AISI) indicate poorer prognosis.
Area of Science:
- Oncology
- Surgical Oncology
- Radiology
Background:
- Non-small cell lung cancer (NSCLC) prognosis is influenced by various factors.
- Body composition and systemic inflammation are increasingly recognized as critical determinants of patient outcomes.
Purpose of the Study:
- To investigate the prognostic value of visceral fat area (VFA) and subcutaneous fat area (SFA) in NSCLC patients.
- To assess the impact of the systemic immune-inflammation index (SII) and AISI on postoperative survival in NSCLC.
Main Methods:
- A cohort of 266 NSCLC patients undergoing surgery was analyzed.
- Kaplan-Meier survival analysis and Cox proportional hazards models were employed to evaluate overall survival (OS) and progression-free survival (PFS).
- Abdominal fat areas (VFA, SFA) were quantified using CT imaging, alongside inflammatory markers (SII, AISI).
Main Results:
- Higher VFA was associated with improved OS and PFS (p < 0.05).
- Elevated SII and AISI were identified as risk factors for poorer OS and PFS (p < 0.05).
- A combination of high VFA and low SFA demonstrated the longest median OS (108 months) and PFS (85 months), with the lowest inflammatory markers.
Conclusions:
- VFA, SFA, SII, and AISI serve as significant prognostic markers for postoperative survival in NSCLC.
- Excessive SFA may exacerbate systemic inflammation, potentially diminishing the protective effects of VFA.
- These findings can guide targeted nutritional and interventional strategies for high-risk NSCLC patients.
