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STEC colitis mimicking acute severe colitis with life-threatening consequences: a case report
T Hendrickx1, M Peetermans2,3, A D'Hoore4
1Department of Gastroenterology, UZ Leuven, Leuven, Belgium.
Acta Gastro-Enterologica Belgica
|March 3, 2024
Summary
Shiga-toxin producing Escherichia coli (STEC) can cause acute colitis mimicking ulcerative colitis. Promptly exclude Shiga toxin-induced hemolytic uremic syndrome (STEC-HUS) in severe colitis cases using multiplex-PCR.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Nephrology
Background:
- Acute colitis is a common manifestation of Shiga-toxin producing Escherichia coli (STEC) infection.
- STEC infection poses a risk for developing Shiga toxin-induced hemolytic uremic syndrome (STEC-HUS).
Observation:
- A patient with refractory ulcerative colitis presented with symptoms mimicking a colitis flare.
- Differentiating STEC-HUS from ulcerative colitis exacerbation was clinically challenging due to overlapping presentations.
Findings:
- STEC-induced colitis can present similarly to acute severe ulcerative colitis.
- Early recognition of STEC-HUS is critical due to potential severe complications, including neurological damage and fatality.
Implications:
- STEC-HUS should be promptly excluded in patients presenting with acute severe ulcerative colitis.
- Multiplex-PCR assay on fecal samples is recommended for early diagnosis and management of STEC-HUS.
- This distinction is crucial for preventing life-threatening complications associated with STEC-HUS.
Keywords:
STEC-HUShaemolytic uremic syndrome (HUS)inflammatory bowel disease (IBD)thrombotic microangiopathy (TMA)ulcerative colitis (UC)More Related Videos
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