Relation of Streptococcus Pyogenes tonsillitis isolate to antimicrobial agents and its infection treatment
Daryna B Pylypiv1, Boris M Sharga1, Olexandr A Rishko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Abstract:
We reported the case of tonsillitis treatment in a 17-years-old boy with use of chemical non-antibiotic preparations, plant derived products and antibiotic benzathine phenoxymethylpenicillin. The antimicrobial agents for treatment were selected on the basis of their activity against a disease agent, the group A β-hemolytic strain Streptococcus pyogenes BS1 isolated from a patient. The bacterium was susceptible in vitro to β-lactams, with largest zones conditioned by penicillin G and benzathine phenoxymethylpenicillin discs, to fluoroquinolones and to cephems, with exception of cefazolin. Lincosamide clindamycin, macrolide spiramycin, aminoglycoside gentamicin, erythromycin, tetracycline and combination of sulfamethoxazole and trimethoprim were inactive against this bacterium. The Streptococcus pyogenes BS1 demonstrated intermediate susceptibility to the cephalosporin cephalexin, fluoroquinolone lomefloxacin and glycopeptide vancomycin. Non-antibiotic preparations were evaluated against Streptococcus pyogenes BS1 also. Among them "Stomatidin", "Chlorophyllipt", and phages of "Pyofag" were more effective than "Decatylen", "Decasan" and "Furadonin" in vitro. The antimicrobial applications of "Stomatidin", "Chlorophyllipt" and phages of "Pyofag" in the patient were less effective compared to the result of antibiotic benzathine phenoxymethylpenicillin treatment. Complete recovery of the patient was achieved with use of this antibiotic and Calendula flower extract as an local anti-inflammatory agent.
Insights
Benzathine phenoxymethylpenicillin effectively treated tonsillitis caused by Streptococcus pyogenes. While some non-antibiotic agents showed in vitro activity, the antibiotic proved superior for patient recovery.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Tonsillitis is a common infection, often caused by Group A Streptococcus pyogenes.
- Effective antimicrobial treatment is crucial to prevent complications.
Observation:
- A 17-year-old boy with tonsillitis was treated with various agents, including benzathine phenoxymethylpenicillin, non-antibiotic preparations, and plant-derived products.
- In vitro susceptibility testing revealed Streptococcus pyogenes BS1 was most sensitive to penicillin G and benzathine phenoxymethylpenicillin among beta-lactams, fluoroquinolones, and cephems.
- Several other antibiotic classes and non-antibiotic preparations showed limited or no efficacy against the isolated strain.
Findings:
- Benzathine phenoxymethylpenicillin demonstrated significant in vitro activity against Streptococcus pyogenes BS1.
- Non-antibiotic agents like "Stomatidin", "Chlorophyllipt", and "Pyofag" phages showed some in vitro effectiveness but were less potent than benzathine phenoxymethylpenicillin.
- The patient achieved complete recovery with benzathine phenoxymethylpenicillin and Calendula flower extract for local anti-inflammatory effects.
Implications:
- Benzathine phenoxymethylpenicillin remains a highly effective antibiotic for treating Streptococcus pyogenes-induced tonsillitis.
- While novel non-antibiotic agents warrant further investigation, conventional antibiotics are critical for achieving complete patient recovery.
- This case highlights the importance of targeted antimicrobial selection based on in vitro susceptibility testing.
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