Treatment and Mortality Following Cancer Diagnosis Among People With Non-affective Psychotic Disorders in Ontario, Canada: A Retrospective Cohort Study

  • 0Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

|

|

Summary

This summary is machine-generated.

People with psychotic disorders receive less cancer treatment and face a higher mortality risk post-diagnosis. This study highlights disparities in cancer care access for this population, contributing to poorer outcomes.

Area Of Science

  • Oncology
  • Psychiatry
  • Health Services Research

Background

  • Individuals with psychotic disorders exhibit elevated mortality rates after cancer diagnosis.
  • Disparities in cancer-related treatment's impact on this mortality gap remain unclear.

Purpose Of The Study

  • To investigate if individuals with psychotic disorders receive less cancer treatment.
  • To compare cancer-related mortality between individuals with and without psychotic disorders.

Main Methods

  • Retrospective cohort study using Ontario Health administrative data (1995-2019).
  • Included 24,944 cancer patients, comparing those with non-affective psychotic disorder (NAPD) to a general population cohort.
  • Utilized Cox proportional hazards models to analyze treatment receipt and all-cause/cancer-related mortality, adjusting for clinical factors.

Main Results

  • People with NAPD were less likely to receive cancer treatment (HR=0.87).
  • Individuals with NAPD faced a significantly higher risk of all-cause mortality (HR=1.68) compared to those without psychosis.

Conclusions

  • Lower treatment rates for individuals with psychotic disorders may contribute to their increased cancer mortality risk.
  • Identified disparities in cancer care access warrant further investigation into mediating factors and targeted interventions.

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia 01:29

86

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Cancer Survival Analysis 01:21

345

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Personality Disorders: Paranoid and Schizoid 01:22

41

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...

Psychosis and Antipsychotic Drugs: Overview 01:28

253

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...

Treatment Strategies for Psychological Disorders 01:24

123

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...

Psychosis: Goals of Pharmacotherapy 01:26

128

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.