Related Experiment Video
Updated: Jul 1, 2025
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
Association of serum albumin with heart failure mortality with NYHA class IV in Chinese patients: Insights from
Yun Chen1, Xian-Bin Cai1, Xin Yao1
1Department of Gastroenterology, First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou 515041, Guangdong, China; Shantou University Medical College, 22 Xinling Road, Shantou 515041, Guangdong, China.
Insights
Low serum albumin levels predict higher 28-day mortality in Chinese heart failure patients. Albumin can serve as an independent predictor for all-cause death in these patients.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Public Health
Background:
- Low serum albumin is linked to increased mortality in various diseases.
- The prognostic value of albumin in Chinese heart failure patients remains unclear.
Purpose of the Study:
- To investigate the association between serum albumin levels and 28-day mortality.
- Focus on hospitalized Chinese patients with New York Heart Association (NYHA) Class IV heart failure.
Main Methods:
- Included 2008 Chinese patients.
- Utilized Cox proportional hazards regression and smooth curve fitting.
- Assessed associations using Forest plot analysis across subgroups.
Main Results:
- NYHA IV patients had lower albumin and higher 28-day mortality than NYHA II-III patients.
- Serum albumin on admission was an independent inverse predictor of mortality (HR: 0.80; 95% CI: 0.66-0.96).
- Higher albumin levels correlated with decreased 28-day mortality.
Conclusions:
- Serum albumin is negatively associated with 28-day mortality in NYHA IV heart failure patients in China.
- Serum albumin can be utilized as an independent prognostic marker.
Background:
Studies have proved that low albumin level is associated with increased mortality in most diseases, such as chronic kidney disease and hepatic cirrhosis. However, the relationship between albumin and all-cause death in heart failure patients in China is still unclear.
Objectives:
We aimed to investigate the association between albumin level and 28-day mortality in Chinese hospitalized patients with NYHA IV heart failure.
Methods:
A total of 2008 Chinese patients were included. The correlation between serum albumin level and mortality was tested using a cox proportional hazards regression model. The smooth curve fitting was used to identify non-linear relationships between serum albumin and mortality. The Forest plot analysis was used to assess the association between albumin and 28-day mortality in different groups.
Results:
Compared with patients with NYHA II-III, patients with NYHA IV had lower albumin level and higher mortality within 28 days. The albumin on admission was independently and inversely associated with the endpoint risk, which remained significant (hazard ratio: 0.80; 95 % confidence interval: 0.66 to 0.96; p = 0.0196) after multivariable adjustment. The smooth curve fitting showed with the increase of albumin, the mortality within 28 days would decrease. A subgroup analysis found that the inverse association between the albumin level and risk of the mortality was consistent across the subgroup stratified by possible influence factors.
Conclusion:
Serum albumin level is negatively associated with 28-day mortality in hospitalized heart failure patients within NYHA IV in China, which can be used as an independent predictor.
More Related Videos
08:04Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
Published on: October 23, 2018
09:44Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Related Concept Videos
01:17Pathophysiology of Heart Failure
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:26Heart Failure Drugs: Inotropic Agents
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:22Heart Failure Drugs: Diuretics