Association of serum albumin with heart failure mortality with NYHA class IV in Chinese patients: Insights from...

Area of Science:

• Cardiology
• Clinical Biochemistry
• Public Health

Background:

• Low serum albumin is linked to increased mortality in various diseases.
• The prognostic value of albumin in Chinese heart failure patients remains unclear.

Purpose of the Study:

• To investigate the association between serum albumin levels and 28-day mortality.
• Focus on hospitalized Chinese patients with New York Heart Association (NYHA) Class IV heart failure.

Main Methods:

• Included 2008 Chinese patients.
• Utilized Cox proportional hazards regression and smooth curve fitting.
• Assessed associations using Forest plot analysis across subgroups.

Main Results:

• NYHA IV patients had lower albumin and higher 28-day mortality than NYHA II-III patients.
• Serum albumin on admission was an independent inverse predictor of mortality (HR: 0.80; 95% CI: 0.66-0.96).
• Higher albumin levels correlated with decreased 28-day mortality.

Conclusions:

• Serum albumin is negatively associated with 28-day mortality in NYHA IV heart failure patients in China.
• Serum albumin can be utilized as an independent prognostic marker.