Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

13.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
13.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.1K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. History Of Tspo Deletion And Induction In Vivo: Phenotypic Outcomes Under Physiological And Pathological Situations

History of Tspo deletion and induction in vivo: Phenotypic outcomes under physiological and pathological situations

Juliette Bréhat1, Leeyah Issop1, Didier Morin1

  • 1INSERM U955-IMRB, Team Ghaleh, UPEC, Ecole Nationale Vétérinaire d'Alfort, Créteil, France.

Biochimie
|March 3, 2024

Related Experiment Videos

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

8.3K
Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
12:47

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

18.8K
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.2K

View abstract on PubMed

Summary
This summary is machine-generated.

The mitochondrial translocator protein (TSPO) remains poorly understood despite decades of research. New animal models are improving knowledge, but TSPO's exact function and therapeutic potential are still unclear.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • The mitochondrial translocator protein (TSPO) is an outer mitochondrial membrane protein with high cholesterol affinity, enriched in steroidogenic tissues.
  • TSPO is implicated in various biological processes, and its dysregulation is linked to several diseases.
  • Despite extensive research, TSPO's precise physiological function remains elusive, partly due to challenges in creating animal models.

Purpose of the Study:

  • To chronologically review the development of TSPO deletion and induction models.
  • To discuss how these models have advanced the understanding of TSPO's role.
  • To highlight persistent questions regarding TSPO's function and therapeutic applications.

Main Methods:

  • Review of historical and recent studies on TSPO.
Keywords:
Animal modelsGlobal deletionTissue specific deletionTissue specific induction

Related Experiment Videos

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

8.3K
Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
12:47

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

18.8K
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.2K
  • Analysis of the impact of genetically modified animal models (deletion and induction) for TSPO.
  • Chronological assessment of research methodologies and findings.

    • Main Results:

    • Early attempts to create TSPO deletion models were unsuccessful, suggesting essentiality.
    • Recent advances in genome modification have enabled the development of various TSPO animal models.
    • These models have significantly enhanced fundamental knowledge but have not fully elucidated TSPO's precise molecular function.

    Conclusions:

    • The development of TSPO animal models has been crucial for advancing research.
    • Despite progress, the exact physiological role of TSPO and its therapeutic targeting remain open questions.
    • Further research using these models is needed to clarify TSPO's function and clinical relevance.
    Translocator protein