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Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

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The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Related Experiment Video

Updated: Jul 1, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Understanding psychosis complexity through a syndemic framework: A systematic review.

Uzma Zahid1, Erin Grace Lawrence2, Daniela Fonseca de Freitas3

  • 1Department of Psychiatry, University of Oxford, Oxford, UK; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Bodleian Health Care Libraries, University of Oxford, Oxford, UK.

Neuroscience and Biobehavioral Reviews
|March 3, 2024
PubMed
Summary

Psychosis is better understood as part of a syndemic, involving interconnected health and social issues. This framework highlights risks and disparities, especially for marginalized groups, guiding better interventions.

Keywords:
FrameworkInterdisciplinarityMethodologyPsychosisSyndemic

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Area of Science:

  • Public Health
  • Psychiatry
  • Sociology

Background:

  • Psychotic conditions present complex challenges, impacting individuals and communities.
  • Syndemic theory provides a framework for understanding interconnected health and social problems in psychosis.

Approach:

  • Systematic review of 7 databases.
  • Inclusion of five original articles examining psychosis within a syndemic context.

Key Points:

  • Findings indicate a syndemic characterized by coexisting health and social conditions.
  • This syndemic is associated with increased psychosis risk, adverse outcomes, and disparities.
  • Ethnic minorities and deprived populations are disproportionately affected.

Conclusions:

  • A new paradigm and datasets are needed to investigate psychosis emergence in syndemics.
  • This approach will guide effective preventive and care interventions.
  • Policies can be developed to improve the health of marginalized communities in precarity.