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Related Experiment Video

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Effectiveness and Safety of Ultra-low-dose Fluorescein Sodium-Guided Resection of Malignant Glioma.

Guoyuan Ling1, Tangjun Guo2, Fangzhou Guo3

  • 1Graduate School, Dalian Medical University, Liaoning Province, China; Department of Neurosurgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.

World Neurosurgery
|March 3, 2024
PubMed
Summary
This summary is machine-generated.

Ultra-low-dose fluorescein sodium (FL)-guided surgery safely and effectively resects malignant gliomas. FL intensity correlates with Ki67, aiding glioma prediction in pathological exams.

Keywords:
Fluorescein sodiumGFAPKi-67Malignant glioma

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Area of Science:

  • Neurosurgery
  • Oncology
  • Medical Imaging

Background:

  • Malignant gliomas pose significant surgical challenges.
  • Fluorescein sodium (FL) is explored for guided tumor resection.
  • Ultra-low doses of FL are investigated for safety and efficacy.

Purpose of the Study:

  • To evaluate the effectiveness and safety of ultra-low dose FL-guided malignant glioma resection.
  • To assess FL's potential in predicting glioma pathological characteristics.

Main Methods:

  • Randomized controlled trial comparing 1 mg/kg (test) and 5 mg/kg (control) FL doses.
  • Inclusion of a retrospective blank control group (no FL guidance).
  • Comparison of surgical outcomes, KPS, PFS, FL sensitivity/specificity, and correlation with GFAP/Ki-67.

Main Results:

  • Higher total tumor resection rates in FL-guided groups (90% test, 86.7% control) vs. blank control (60%).
  • Significant improvements in resection extent, KPS, and 6-month PFS for FL groups compared to blank control.
  • Direct proportionality observed between FL intensity and Ki67 positivity, but not GFAP.

Conclusions:

  • Ultra-low dose FL-guided resection is a safe and effective method for malignant gliomas.
  • FL intensity shows potential as a predictive marker for glioma characteristics, specifically Ki67 expression.