Related Experiment Video

Updated: Jul 1, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

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Role of copper and its complexes in cardiovascular diseases

Wenjun Zhu1, Yiyue Zhang2, Xiuju Luo3

  • 1Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078. 227211066@csu.edu.cn.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|March 3, 2024
PubMed

Insights

Copper is vital for cardiovascular health, with imbalances linked to heart disease. Copper complexes show promise for treating cardiovascular conditions by targeting copper signaling pathways.

Area of Science:

  • Cardiovascular Biology
  • Trace Element Metabolism
  • Pharmacology

Background:

  • Copper is an essential trace element crucial for cardiovascular system function.
  • Copper transport and metabolism involve specific proteins (enzymes, chaperones, transporters).
  • Disrupted copper levels or protein expression correlate with cardiovascular diseases like atherosclerosis and heart failure.

Purpose of the Study:

  • To explore the role of copper in maintaining cardiovascular health.
  • To investigate the therapeutic potential of copper complexes in cardiovascular diseases.
  • To identify new targets for cardiovascular disease prevention and treatment.

Main Methods:

  • Literature review on copper's role in cardiovascular physiology and pathology.
  • Analysis of existing studies on copper complexes (e.g., trientine, copper-aspirinate) in cardiovascular disease models.
  • Exploration of copper ion signaling pathways in cardiovascular health.

Main Results:

  • Copper homeostasis is critical for normal cardiovascular function.
  • Abnormal copper metabolism is implicated in various cardiovascular pathologies.
  • Certain copper complexes demonstrate potential in preventing and treating cardiovascular diseases.

Conclusions:

  • Intervention in copper ion signaling pathways offers a promising therapeutic strategy for cardiovascular diseases.
  • Further research into copper's role and copper complexes may yield novel clinical treatments.
  • Understanding copper's cardiovascular impact can lead to new therapeutic targets.

Keywords:
cardiovascular diseasescoppercopper chaperonescopper complexescopper transporterscopper-based enzymes

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