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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Antimicrobial Proteins01:23

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Related Experiment Video

Updated: Jul 1, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Roles of complement system in psychiatric disorders.

Yajie Huo1, Jie Chen2, Aomei Zhang2

  • 1Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical College, University of South China, Hengyang Hunan 421001, China. 1315396139@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|March 3, 2024
PubMed
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The complement system, crucial for innate immunity, can cause brain damage when overactivated in psychiatric disorders. Understanding its role offers new therapeutic avenues for conditions like schizophrenia and depression.

Keywords:
complementmajor depression disorderpsychiatric disordersschizophrenia

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Area of Science:

  • Neuroimmunology
  • Innate Immune System Research

Background:

  • The complement system, comprising over 50 proteins, is vital for pathogen clearance and maintaining brain homeostasis.
  • Strict regulation of complement activity prevents self-damage, but dysregulation can cause neuronal injury and dysfunction.
  • Alterations in complement molecules are observed in psychiatric diseases, influencing neuronal and glial cell function.

Purpose of the Study:

  • To summarize recent research on the complement system's role in psychiatric disorders.
  • To explore the involvement of complement in schizophrenia, autism spectrum disorder, major depression, bipolar disorder, and anxiety disorder.
  • To identify potential therapeutic strategies targeting complement dysregulation in brain disorders.

Main Methods:

  • Literature review of recent studies on complement system and psychiatric diseases.
  • Analysis of research linking complement molecules to neuronal and glial cell function.
  • Synthesis of findings regarding complement involvement in specific psychiatric conditions.

Main Results:

  • The complement system plays a significant role in the pathogenesis of various psychiatric diseases.
  • Aberrant complement activation in the brain is associated with neuronal damage and dysfunction in these disorders.
  • Changes in complement molecules are implicated in the development and progression of conditions like schizophrenia and depression.

Conclusions:

  • The complement system is a key player in the neurobiology of psychiatric disorders.
  • Targeting the complement cascade presents a promising strategy for novel psychiatric disease treatments.
  • Further research into complement system modulation could lead to innovative preventative and therapeutic approaches.