Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

566
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
566
What is Gene Expression?01:42

What is Gene Expression?

167.5K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
167.5K
Gene-Environment Interactions01:20

Gene-Environment Interactions

315
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
315
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

906
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
906
Introduction to Personality Psychology01:29

Introduction to Personality Psychology

16.6K
Personality encompasses a set of enduring traits and behavioral patterns that define how individuals think, feel, and interact, ultimately shaping their unique identities. The concept of personality has deep historical roots, deriving from the Latin term "persona," which means "mask." This term initially referred to the roles played by actors in ancient theater, signifying the different facets individuals display in various contexts.
Early Theories of Personality
The study of...
16.6K
Personality Theory by Eysenck and Eysenck01:29

Personality Theory by Eysenck and Eysenck

460
Hans and Sybil Eysenck developed a widely recognized theory of personality, which emphasizes the role of temperament and genetically based differences in shaping individual traits. Their theory posits that biological factors primarily determine personality and can be understood through two main dimensions: extroversion/introversion and neuroticism/stability.
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
460

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort.

Aging cell·2026
Same author

Role of resilience in modifying the links between genetic propensity for mental disorders and irritability.

Journal of affective disorders·2026
Same author

Whole blood epigenomic and transcriptomic characterization identifies vulnerable molecular subtypes of chronic coronary disease.

Nature communications·2026
Same author

Brain age prediction in generalized anxiety disorder using a convolutional neural network.

Translational psychiatry·2026
Same author

<i>Trans</i>-eQTLs reveal the architecture of human gene regulatory networks.

medRxiv : the preprint server for health sciences·2026
Same author

Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease.

BMC medicine·2026

Related Experiment Video

Updated: Jul 1, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.9K

Gene expression networks regulated by human personality.

Coral Del Val1,2, Elisa Díaz de la Guardia-Bolívar1, Igor Zwir1,3

  • 1University of Granada, Department of Computer Science and Artificial Intelligence, Andalusian Research Institute in Data Science and Computational Intelligence, Granada, Spain.

Molecular Psychiatry
|March 3, 2024
PubMed
Summary
This summary is machine-generated.

This study reveals a six-gene hub coordinating gene networks for human personality traits, impacting emotional reactivity and concept interpretation through integrated gene expression. This discovery advances our understanding of the genetic basis of personality.

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

713
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.2K

Related Experiment Videos

Last Updated: Jul 1, 2025

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.9K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

713
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.2K

Area of Science:

  • Neurogenetics
  • Systems Biology
  • Behavioral Genetics

Background:

  • Genome-wide association studies (GWAS) have explored human personality genetics, but genome-wide transcription has not been comprehensively studied in this context.
  • Understanding gene expression regulation and function is crucial for characterizing the biological underpinnings of personality traits.

Purpose of the Study:

  • To investigate genome-wide expression profiles in adults to identify key regulatory elements and interactions in gene networks associated with human personality.
  • To characterize the regulation of expression and function in genes related to human personality using a novel multi-omic network analysis approach.

Main Methods:

  • Collected genome-wide expression profiles from 459 adults (Young Finns Study) who completed personality assessments.
  • Employed a multi-omic network analysis approach to identify co-expressed gene sets in relevant brain regions and construct minimum networks.
  • Utilized bioinformatic resources to identify regulatory genes, miRNAs, and ncRNAs involved in personality-related networks.

Main Results:

  • Identified an extrinsic network (45 genes) related to emotional reactivity and an intrinsic network (43 genes) related to interpretation of meaning.
  • Discovered a six-gene control hub (3 miRNAs, 3 protein-coding genes) coordinating interactions between these networks.
  • This hub interacts with over 100 known personality genes and indirectly with over 4000 additional genes, enriched in LLPS-related RNAs and transcription factors.

Conclusions:

  • The identified six-gene hub is central to an integrative network orchestrating information transfer across a large gene system (>4000 genes).
  • These gene expression networks regulate neuronal plasticity, epigenesis, and adaptive functioning, integrating salience and meaning in self-awareness.
  • This study provides novel insights into the complex genetic architecture of human personality through a systems-level gene expression perspective.