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  1. Home
  3. Lymphatic Expression Of The Proliferation Marker Ki67 Is Linked To Sentinel Node Positivity, Recurrence And Mortality In Primary Cutaneous Melanoma.
  1. Home
  3. Lymphatic Expression Of The Proliferation Marker Ki67 Is Linked To Sentinel Node Positivity, Recurrence And Mortality In Primary Cutaneous Melanoma.

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Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality

Samuel X Tan1, Sharene Chong1, Casey Rowe1

  • 1Frazer Institute, University of Queensland, Brisbane, Queensland, Australia.

Experimental Dermatology
|March 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Emergent lymphangiogenesis, indicated by D2-40+/Ki67+ co-expression, signals increased melanoma risk. This finding highlights lymphatic proliferation as a key indicator for melanoma-specific mortality and recurrence in primary cutaneous melanoma patients.

Keywords:
biomarkerimmunofluorescencemelanomapathologyprognosis

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Lymphangiogenesis, the formation of new lymphatic vessels, precedes lymphovascular invasion.
  • Lymphovascular invasion is linked to higher metastasis and mortality risks in primary cutaneous melanoma.
  • Identifying early indicators of melanoma progression is crucial for patient prognosis.

Purpose of the Study:

  • To investigate the association between emergent lymphangiogenesis and prognosis in primary cutaneous melanoma.
  • To evaluate if co-expression of endothelial proteins with Ki67 predicts poorer outcomes.
  • To determine the prognostic value of lymphatic proliferation in melanoma patients.

Main Methods:

  • Retrospective longitudinal study of 264 primary cutaneous melanoma patients.
  • Opal multiplex immunofluorescence staining for endothelial proteins (CD31, D2-40) and Ki67.
  • Multivariate Cox regression analysis to assess the association between endothelial Ki67 positivity and clinical outcomes.

    • Main Results:

    • Co-expression of D2-40+/Ki67+ was significantly associated with increased melanoma-specific mortality (aHR: 2.03) and recurrence (aHR: 1.70).
    • CD31+/Ki67+ co-expression did not show prognostic significance in this cohort.
    • Lymphatic proliferation, identified by D2-40+/Ki67+ co-expression, predicted poorer outcomes.

    Conclusions:

    • Emergent lymphangiogenesis, specifically D2-40+/Ki67+ co-expression, is a significant predictor of adverse outcomes in primary cutaneous melanoma.
    • This marker of lymphatic proliferation may indicate a higher risk of metastasis and mortality.
    • D2-40+/Ki67+ co-expression can aid in risk stratification for melanoma patients.