Related Experiment Video
Updated: Jul 1, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
[Research Progress in the Relationship Between Neurofilament Light Chain Protein and Cognitive Impairment in Type 2
Qing-Yi Cao1, Yi Tian1, Jin-Nong Wang1
1Department of Anesthesiology,Affiliated Haikou Hospital,Central South University Xiangya School of Medicine,Haikou 570100,China.
Abstract:
Metabolic abnormality in type 2 diabetes mellitus(T2DM)can cause damage to the central nervous system,leading to cognitive decline.Neurofilament light chain protein(NFL),as a blood marker of neuroaxonal injuries,is significantly associated with the onset of cognitive impairment and affected by the renal function.It can participate in the development of cognitive impairment in T2DM through inflammation,blood-brain barrier breakdown,interaction between microglia and neurons,and Tau protein phosphorylation.We reviewed the mechanism of the occurrence and development of NFL-involved cognitive impairment and the correlation between NFL and renal function in T2DM,hoping to provide a basis for early diagnosis and treatment of cognitive impairment in T2DM patients.
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Neural Regulation

