Parental cardiometabolic multimorbidity and subsequent cardiovascular incidence in middle-aged adults: A prospective...

Area of Science:

• Cardiology
• Genetics
• Public Health

Background:

• Cardiometabolic multimorbidity (CMD), the co-occurrence of conditions like coronary heart disease (CHD), diabetes, and stroke, is rising.
• The impact of parental CMD on cardiovascular disease (CVD) risk in middle-aged adults is not well understood.

Purpose of the Study:

• To investigate the association between parental CMD patterns and the incidence of CVD in middle-aged adults.
• To assess if parental CMD patterns improve CVD risk prediction models.

Main Methods:

• Utilized UK Biobank data from 71,923 participants (40-55 years old) without prior CVD.
• Developed a weighted score to categorize parental CMD burden (non-CMD, low, middle, high).
• Employed Cox proportional hazard models to analyze CVD incidence and risk prediction.

Main Results:

• A high burden of parental CMD was linked to a 94% increased risk of CVD.
• An exposure-response relationship was observed between parental CMD burden and CVD risk.
• Inclusion of parental CMD patterns slightly enhanced CVD risk prediction, particularly for CHD.

Conclusions:

• Increased parental CMD burden is associated with higher CVD incidence in middle-aged adults.
• Parental CMD patterns offer valuable insights for primary CVD prevention efforts.