Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.The fibrinogen to prealbumin ratio (FPR) shows prognostic value in resectable gastric cancer. A nomogram incorporating FPR demonstrates strong predictive ability for patient outcomes.
Area Of Science
- Oncology
- Biomarkers
- Surgical Oncology
Background
- The fibrinogen to prealbumin ratio (FPR) is linked to outcomes in various cancers.
- Its prognostic role in resectable gastric cancer remains unclear.
Purpose Of The Study
- To investigate the prognostic significance of the FPR in patients with resectable gastric cancer.
- To develop and validate a predictive nomogram for gastric cancer prognosis using FPR.
Main Methods
- A cohort of 760 patients with resectable gastric cancer was analyzed.
- Receiver operating characteristic (ROC) curve analysis determined optimal FPR cutoff values.
- Univariate and multivariate Cox regression analyses identified prognostic factors for nomogram construction.
Main Results
- Higher FPR was associated with older age and increased lymph node metastasis (P < 0.05).
- Multivariate analysis identified age, T stage, N stage, radical resection, and FPR as independent predictors of overall survival (OS).
- The developed nomogram demonstrated good predictive accuracy (AUC = 0.859).
Conclusions
- The FPR is a potential prognostic biomarker for resectable gastric cancer.
- A nomogram integrating FPR offers valuable predictive capabilities for clinical decision-making and treatment strategies.
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