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Related Experiment Video

Updated: Jul 1, 2025

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
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Gastric Small Cell Neuroendocrine Carcinoma With Loss of Epithelial Markers Expression.

Rin Yamada1, Satoshi Umemoto2, Kimihiro Yonemitsu2

  • 1Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Cancer Diagnosis & Prognosis
|March 4, 2024
PubMed
Summary
This summary is machine-generated.

Accurate diagnosis of gastric small cell neuroendocrine carcinoma (SCNEC) is crucial due to its aggressive nature. This case highlights that SCNEC can be negative for epithelial markers, emphasizing the importance of neuroendocrine markers for diagnosis.

Keywords:
Gastric cancerkeratinneuroendocrine carcinomasmall cell neuroendocrine carcinomastomach

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Gastric small cell neuroendocrine carcinoma (SCNEC) is more aggressive than adenocarcinoma.
  • Platinum-based chemotherapy is recommended for SCNEC, similar to pulmonary SCNEC.
  • Accurate pathological diagnosis is critical for appropriate treatment.

Purpose of the Study:

  • To report a case of gastric SCNEC with unusual negative epithelial marker expression.
  • To highlight diagnostic challenges and key features of gastric SCNEC.

Main Methods:

  • Case presentation of a 63-year-old male with melena.
  • Gastroscopy revealing a Borrmann type 3 lesion.
  • Distal gastrectomy with D2 lymphadenectomy.
  • Microscopic examination and immunohistochemical analysis.

Main Results:

  • Microscopic examination revealed SCNEC with a minor adenocarcinoma component.
  • Immunohistochemistry showed diffuse positivity for neuroendocrine markers (synaptophysin, CD56, INSM1) and focal positivity for chromogranin A.
  • Complete negativity for epithelial markers (keratins, EMA) was observed.

Conclusions:

  • Gastric SCNEC can exhibit diffuse positivity for neuroendocrine markers and negativity for epithelial markers.
  • Diagnostic clues include neuroendocrine marker positivity and transition from adenocarcinoma.
  • SCNEC diagnosis should not be ruled out solely based on negative epithelial marker results.