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A Case of Tizanidine Withdrawal and Road to Recovery

Tomas Escobar Gil1, Kevin J McGeorge1, Aaron J Jones1

  • 1Internal Medicine, University of New Mexico School of Medicine, Albuquerque, USA.

Cureus
|March 4, 2024
PubMed

This case report highlights the complexities of tizanidine withdrawal in a 68-year-old woman with chronic pain. Tizanidine, a widely used imidazole-derived muscle relaxant, poses challenges due to the absence of standardized withdrawal protocols. The patient's presentation included hypertension and tachycardia following a gradual reduction in her outpatient tizanidine dose. During the de-escalation of tizanidine, the patient experienced withdrawal symptoms, including severe body aches, hypertension, and tachycardia. Management during withdrawal involved a unique approach using a one-time dose of phenobarbital, a measure that allowed the resolution of hemodynamic instability and pain with complete discontinuation of tizanidine. The ultimate decision to transition the patient to methocarbamol and stop taking tizanidine for pain control highlights the importance of individualized care. The patient has responded to this therapy upon follow-up.

Keywords:
addictioninternal medicineneurologyoverdosepainphenobarbital therapypsychiatrytizanidinetoxicologywithdrawal

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