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Risk Factors of Cardiovascular and Cerebrovascular Events in Patients With Uraemia Complicated With Hypertension
Awais Ahmed Nizami1, Waqar Mustafa2, Mamoon Qadir3
1Cath Lab, Shahida Islam Medical College, Lodhran, PAK.
Cureus
|March 4, 2024
Summary
Patients undergoing maintenance haemodialysis (MHD) with hypertension and uraemia face significant risks of major adverse cardiovascular and cerebrovascular events (MACCE). Key risk factors include diabetes, elevated triglycerides, and blood pressure variability.
Area of Science:
- Nephrology
- Cardiology
- Hypertension Management
Background:
- Uraemia and hypertension significantly increase cardiovascular and cerebrovascular event risk.
- Maintenance haemodialysis (MHD) is a critical treatment for end-stage renal disease.
- Identifying risk factors for major adverse cardiovascular and cerebrovascular events (MACCE) in this population is crucial for improved patient outcomes.
Purpose of the Study:
- To investigate the risk factors associated with MACCE in patients with uraemia and hypertension undergoing MHD.
- To analyze clinical and laboratory indicators predictive of MACCE in this patient cohort.
Main Methods:
- Retrospective analysis of clinical and laboratory data from 156 uraemia patients with hypertension undergoing MHD.
- Data collected from Abbas Institute of Medical Sciences, Pakistan (February 2018 - February 2022).
- Inclusion and exclusion criteria were applied for patient recruitment.
Main Results:
- An incidence of 48.08% for MACCE was observed during MHD treatment.
- Significant differences (P<0.05) in diabetes, body mass growth rate, triglyceride (TG), NT-proBNP, and blood pressure variability (SBP-SD, SBP-CV, DBP-SD, DBP-CV) were noted between MACCE and non-MACCE groups.
- Diabetes, TG, NT-proBNP, and blood pressure variability were identified as independent risk factors for MACCE.
Conclusions:
- Diabetes, elevated triglycerides, NT-proBNP, and blood pressure variability are significant risk factors for MACCE in uraemic patients with hypertension on MHD.
- These findings highlight the importance of managing these factors to reduce adverse cardiovascular and cerebrovascular outcomes.
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