Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

638
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
638
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

961
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
961
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

561
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
561
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

59
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
59

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strain sharing and persistence of microbial pathogens colonizing the skin of residents in a regional nursing home network.

Nature communications·2026
Same author

Permissive skin microbiomes in WHIM syndrome: HPV and pathogen expansion.

The Journal of investigative dermatology·2026
Same author

Expansion of pathogens and restoration of human skin microbiome in CD4 T-cell lymphopenia.

The Journal of investigative dermatology·2026
Same author

Resolution of PML after Treatment with Virus-Specific T Cells and HCT.

The New England journal of medicine·2026
Same author

The human skin virome: Ecological dynamics, aberrant profiles, and therapeutic opportunities.

Cell host & microbe·2026
Same author

Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.

The Journal of allergy and clinical immunology·2026

Related Experiment Video

Updated: May 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.5K

Calciphylaxis in POEMS syndrome: Case report.

Danica Novacic1, Thomas Uldrick2, Alina Dulau-Florea3

  • 1Undiagnosed Diseases Program, National Institutes of Health (NIH) Common Fund, Office of the Director, NIH, Bethesda, MD, USA.

Rare (Amsterdam, Netherlands)
|March 4, 2024
PubMed
Summary

Calciphylaxis, a rare complication of POEMS Syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, Skin changes), can precede the full syndrome diagnosis. Early recognition and treatment of calciphylaxis in POEMS patients is crucial.

Keywords:
CalciphylaxisCase reportMyelomaPOEMS

More Related Videos

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

3.9K
Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
07:14

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

2.6K

Related Experiment Videos

Last Updated: May 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.5K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

3.9K
Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
07:14

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

2.6K

Area of Science:

  • Vascular Medicine
  • Hematology
  • Dermatology

Background:

  • POEMS Syndrome is a rare multisystem disorder.
  • Calciphylaxis is a severe microvascular complication characterized by vascular calcification and skin necrosis.
  • Calciphylaxis is an uncommon manifestation of POEMS Syndrome.

Purpose of the Study:

  • To report a case of POEMS Syndrome where calciphylaxis was the initial presenting manifestation.
  • To highlight the potential for calciphylaxis to antedate the diagnosis of POEMS Syndrome.
  • To discuss the management and outcomes of this rare presentation.

Main Methods:

  • Case report of a patient with extensive calciphylaxis and subsequent diagnosis of POEMS Syndrome.
  • Diagnostic workup included skin biopsy for calciphylaxis and bone marrow biopsy for plasma cell assessment.
  • Treatment involved supportive care for calciphylaxis and chemotherapy for POEMS Syndrome.

Main Results:

  • The patient presented with severe calciphylaxis, including necrotic skin lesions and acute kidney injury.
  • POEMS Syndrome was diagnosed based on clinical criteria and bone marrow findings of lambda chain restricted plasma cells.
  • Multimodality treatment led to improvement in both calciphylaxis and POEMS Syndrome manifestations.

Conclusions:

  • Calciphylaxis can be a prominent and early feature of POEMS Syndrome.
  • Recognition of calciphylaxis may prompt earlier diagnosis of underlying POEMS Syndrome.
  • Integrated management of calciphylaxis and POEMS Syndrome is essential for patient outcomes.